Weems is a co-founder of the OBIE Award-winning, New York-based performance company The Builders Association. Under Weems' direction over the past two decades, the company has been recognized internationally as a leader of theatrical innovation, incorporating actors with audio and visual elements to create interdisciplinary, multi-dimensional stage performances. The company's work has been presented at the Brooklyn Academy of Music, the Singapore Arts Festival, London's Barbican Centre, Romaeuropa Festival, the Festival Iberoamericano de Teatro de Bogota, and the Melbourne International Arts Festival, among hundreds of others. Current Builders Association productions under Weems' direction include Sontag:Reborn, a story employing Susan Sontag's personal journals to trace her transformation from teenager to world-renowned author and activist, and House/Divided, which uses Steinbeck's classic The Grapes of Wrath as a narrative backbone to tell contemporary tales of foreclosure.
In addition to directing theater, Weems' expertise includes dramaturgy, interdisciplinary media, and the intersection of the arts with technology. Early in her career, Weems worked as a dramaturg with The Wooster Group. More recently, she directed a multimedia workshop with Disney Creative Entertainment and Walt Disney Imagineering. Weems serves on the boards of the Art Matters foundation, Arts Presenters, and the artists' colony Yaddo, as well as the advisory committee of the Center for Research in Engineering, Media and Performance at UCLA. In addition to her work with The Builders Association, Weems is currently collaborating with David Byrne and Fatboy Slim on "Here Lies Love," an original theater/music event. She is the co-author of Art Matters: How The Culture Wars Changed America (NYU Press, 2001) and The Builders Association: Cross-medium Encounters in Contemporary Performance (MIT Press, 2011), which documents the evolution of the company's influences and productions.